Globally, we are witnessing an ever-increasing disease burden associated with increasingly comorbid and ageing populations. Further, the impact of COVID-19 pandemic has underscored the importance of establishing a critical care system within the NHS that is more budget-efficient, personalised, and less invasive. Developments in technologies such as AI, genomics, VR/AR, imaging, and robotics can help address some of these challenges. Innovative UK SMEs are contributing to major breakthroughs that will lead to improvements in the surgical pathway over the next few years. The report will look at market opportunities in surgery, highlight the innovative SMEs operating in this area, and review the patent landscape.